PacBio has issued a formal product obsolescence notice for several of its Revio consumables, as the company transitions to its newer SPRQ chemistry platform. 

Key Dates for Discontinued Products:

• Revio HiFi prep kit 96
  o    Last order date: July 18, 2025
  o    Last ship date: August 15, 2025
• Other original Revio consumables (including polymerase kits, sequencing plates, and reagent kits)
  o    Last order date: October 3, 2025
  o    Last ship date: December 15, 2025

Revio SMRT Cells are not affected by this change and will continue to be available and supported.

Recommended Alternatives

PacBio recommends upgrading to the SPRQ chemistry kits and using Revio software version 13.3 to benefit from:

• 33% higher yield per SMRT Cell
• 4× lower DNA input requirements
• 10% increase in 5mC CpG methylation calling accuracy
• On-instrument 6mA methylation calling to support the Fiber-seq assay

If your department is using any of the affected products, we encourage you to begin planning your transition as soon as possible.